MyBioSource.com's Rat Anti-F4/80, Pan Macrophages Antibody is a Rat monoclonal antibody. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: Flow Cytometry, Immunohistochemistry, and Western Blot.
Description
Mouse F4/80 glycoprotein contains seven-transmembrane (TM7) regions, which anchor the protein in the cell membrane, and thereby shows similarity in this region to G-protein-coupled receptors. The F4/80 molecule shares overall structural homology to other members of the epidermal growth factor (EGF)-TM7 family. The antigen is detected on tissue fixed macrophages in all organs tested so far (spleen, lymph nodes, thymus, liver, skin). It is also present on Langerhans cells in the skin and Kupffer cells in the liver. It is absent on granulocytes, lymphocytes and trombocytes. The expression of F4/80 increases upon maturation of macrophage precursors in bone marrow and blood as well as in ontogeny